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Results for "

natural cytotoxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Apoptosis (4) ATM/ATR (1) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (1) CDK (1) DNA Alkylator/Crosslinker (1) EGFR (1) Endogenous Metabolite (4) Fungal (2) Hedgehog (1) HIV (1) HIV Integrase (1) Isotope-Labeled Compounds (1) Parasite (1) Phosphatase (1) ROS Kinase (1) STAT (2) TNF Receptor (2) Tyrosinase (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (8) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8088

Neolancerin

Others Cancer

Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

Neolancerin	Others	Cancer
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-156186

Anticancer agent 160	Others	Cancer
Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC₅₀=5.0 μM .

HY-122948

Isogambogenic acid	Others	Cancer
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N8317

Rubicordifolin	Others	Cancer
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

HY-N8915

Deoxyflindissone	Others	Others
Deoxyflindissone (Compound 13) is a triterpenoid compound. Deoxyflindissone is isolated from natural Cornus walteri .Deoxyflindissone has significant cytotoxic activity .

HY-N10363

Pixinol	Others	Cancer
Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC₅₀=71 µM and 43 µM, respectively) .

HY-136689

Taxin B

Others Cancer

Taxin B is a natural product with cytotoxicity effects .
HY-N6582

Flavokawin C

Others Cancer

Flavokawin C is a natural compound with antioxidative and cytotoxicity .
HY-N1155

Theviridoside

Others Cardiovascular Disease

Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.
HY-142007

Epothilone D1

Others Others

Epothilone D1 is an isolated natural product that shows cytotoxicity against mouse fibroblasts.
HY-N3430

Kaempferol tetraacetate

AF33
Others Cancer

Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .
HY-133220

Guajadial E

Others Cancer

Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .
HY-133220A

Guajadial F

Others Cancer

Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .
HY-N7011

Epicorynoxidine

Others Inflammation/Immunology

Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL .
HY-W010533

(E)-2-Methyl-2-pentenoic acid

Others Others

(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .
HY-N1081A

Viteralone

(S)-Viteralone
Others Cancer

Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

Taxin B	Others	Cancer
Taxin B is a natural product with cytotoxicity effects .

Flavokawin C	Others	Cancer
Flavokawin C is a natural compound with antioxidative and cytotoxicity .

Theviridoside	Others	Cardiovascular Disease
Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.

Epothilone D1	Others	Others
Epothilone D1 is an isolated natural product that shows cytotoxicity against mouse fibroblasts.

Kaempferol tetraacetate AF33	Others	Cancer
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

Guajadial E	Others	Cancer
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

Guajadial F	Others	Cancer
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

Epicorynoxidine	Others	Inflammation/Immunology
Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL .

(E)-2-Methyl-2-pentenoic acid	Others	Others
(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .

Viteralone (S)-Viteralone	Others	Cancer
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-N12524

Cyclo(prolyltyrosyl)	Bacterial	Infection Cancer
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-Y0790

Cuminaldehyde p-Isopropylbenzaldehyde	Endogenous Metabolite	Cancer
Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-133223

Hispidanin B

Others Cancer

Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

Hispidanin B	Others	Cancer
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

HY-N1266

Scutebata B	Others	Others
Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC₅₀ values of 10.27～28.48 μM .

HY-142102

T988C

(+)-T988C
Others Cancer

T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .

T988C (+)-T988C	Others	Cancer
T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	ADC Cytotoxin	Cancer
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-143242

Phidianidine B	Others	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

HY-N8679

Physalin C

Endogenous Metabolite Cancer

Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-N1318S

Salvigenin-d9 Psathyrotin-d₉	Autophagy	Neurological Disease Inflammation/Immunology Cancer
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties[1][2].

HY-N7933

Tetracosane ALKANE C24	Apoptosis	Inflammation/Immunology
Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .

HY-W024604

4,4-Dimethyl-2-cyclopenten-1-one 4,4-Dimethylcyclopent-2-enone	Others	Cancer
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .

HY-N2445

Flavokawain C 1 Publications Verification	Apoptosis	Cancer
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-N3916

Galanolactone (+)-Galanolactone	Fungal	Infection
Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC₅₀ of 38.5 µg/ml .

HY-129148

Ganoderic acid AM1 GAAM1	Others	Cancer
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-P0219

Microcystin-LA	Phosphatase	Cancer
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively .

HY-N8846

dl-Aloesol	Fungal	Infection
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .

HY-N2852

α-Terthienylmethanol	Others	Others
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .

HY-N12192

Ebenifoline E-II

Others Others

Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

Ebenifoline E-II	Others	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

HY-N1318

Salvigenin 2 Publications Verification Psathyrotin	Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-N3722

O-Demethylmurrayanine	Others	Cancer
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC₅₀ values in the range 4.42-7.59 μg/mL .

HY-156089

Triptoquinone H	Others	Inflammation/Immunology Cancer
Triptoquinone H is a class of natural product isolated from traditional Chinese medicine Tripterygium hypoglaucu. Triptoquinone H has strong cytotoxic, immunomodulatory and anti-inflammatory activities. Triptoquinone H can be used for cancer or inflammatory diseases research .

HY-N12128

Ophiopogonin R	Others	Cancer
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-Y0493

HODHBt HOOBt	STAT HIV	Infection Cancer
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N8739

2-Hydroxyxanthone	Endogenous Metabolite	Cancer
2-Hydroxyxanthone (Compound 3) is an isoprene flavone derived from Calophyllum inophyllum. 2-Hydroxyxanthone has an obvious killing effect on K562 cells .

HY-W015307S

4-Ethyloctanoic acid-13C2	Biochemical Assay Reagents Isotope-Labeled Compounds	Others
4-Ethyloctanoic acid- ¹³C₂ is ¹³C labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-P9977

Amivantamab 1 Publications Verification JNJ-61186372	EGFR	Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-N11519

Polyporusterone C	Others	Cancer
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC₅₀s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .

HY-125098

Illudin S	DNA Alkylator/Crosslinker Apoptosis	Infection Cancer
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N3627

Coronalolide methyl este NSC 680073	Others	Cancer
Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC₅₀ values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively .

HY-N0446

10-Methoxycamptothecin	ADC Cytotoxin	Cancer
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-N11651

Peganumine A	Others	Others
Peganumine A is a natural product that can be found in Peganum harmala. Peganumine A shows cytotoxicity with IC₅₀s of5.8, 38.5, 40.2, 55.4 µM for HL-60, MCF-7, PC-3, and HepG2 cells ,respectively .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Parasite	Infection
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

Cat. No.	Product Name	Target	Research Area

HY-P9977

Amivantamab 1 Publications Verification JNJ-61186372	EGFR	Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-P99622

Flanvotumab IMC-20D7S	Tyrosinase	Cancer
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance .

HY-P99055

Urelumab	Inhibitory Antibodies	Inflammation/Immunology Cancer
Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P99167

Lucatumumab HCD122	TNF Receptor	Cancer
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8088

Neolancerin	other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-122948

Isogambogenic acid	Flavonoids Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Others
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N8317

Rubicordifolin	Structural Classification Natural Products Source classification Rubiaceae Plants Rubia cordifolia L.	Others
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

HY-N8915

Deoxyflindissone	Triterpenes Structural Classification Cornaceae Terpenoids Source classification Cornus walteri Wangerin Plants	Others
Deoxyflindissone (Compound 13) is a triterpenoid compound. Deoxyflindissone is isolated from natural Cornus walteri .Deoxyflindissone has significant cytotoxic activity .

HY-N10363

Pixinol	Triterpenes Classification of Application Fields Juglandaceae Terpenoids Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants Disease Research Fields Cancer	Others
Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC₅₀=71 µM and 43 µM, respectively) .

HY-136689

Taxin B	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	Others
Taxin B is a natural product with cytotoxicity effects .

HY-N6582

Flavokawin C	Structural Classification Chalcones Flavonoids Humulus lupulus L. Source classification Plants Moraceae	Others
Flavokawin C is a natural compound with antioxidative and cytotoxicity .

HY-N1155

Theviridoside	Cardiovascular Disease other families Iridoids Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	Others
Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.

HY-N3430

Kaempferol tetraacetate AF33	Structural Classification Flavonoids Flavones Source classification Rosaceae Plants Fragaria × ananassa Duch.	Others
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

HY-133220

Guajadial E	Structural Classification Source classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants	Others
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

HY-133220A

Guajadial F	Structural Classification Other Monoterpenes Terpenoids Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

HY-N7011

Epicorynoxidine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology	Others
Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL .

HY-N1081A

Viteralone (S)-Viteralone	Terpenoids Verbenaceae Sesquiterpenes Plants Vitex negundo Linn.	Others
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-N12524

Cyclo(prolyltyrosyl)	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Endogenous metabolite	Bacterial
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-Y0790

Cuminaldehyde p-Isopropylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Callicarpa arborea Roxb. Umbelliferae Plants Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-133223

Hispidanin B	Structural Classification Isodon hispidus (Bentham) Murata Terpenoids Labiatae Source classification Diterpenoids Plants	Others
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

HY-N1266

Scutebata B	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC₅₀ values of 10.27～28.48 μM .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Structural Classification Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Cytotoxin
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-143242

Phidianidine B	Alkaloids Microorganisms Classification of Application Fields Marine natural products Other Diseases Disease Research Fields Marine microorganism	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

HY-N8679

Physalin C	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	Endogenous Metabolite
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-W024604

4,4-Dimethyl-2-cyclopenten-1-one 4,4-Dimethylcyclopent-2-enone	Apocynaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Apocyniveneti Folium Cancer	Others
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .

HY-N2445

Flavokawain C 1 Publications Verification	Chalcones Flavonoids other families Classification of Application Fields Source classification Piper methysticum Forst Phenols Polyphenols Piperaceae Plants Disease Research Fields Cancer	Apoptosis
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-129148

Ganoderic acid AM1 GAAM1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-N1912

Andropanolide	Structural Classification Natural Products Andrographis paniculata (Burm. F.) Nees Acanthaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Others
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-P0219

Microcystin-LA	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Phosphatase
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively .

HY-N8846

dl-Aloesol	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Fungal
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .

HY-N2852

α-Terthienylmethanol	Structural Classification Natural Products Source classification Alysicarpus ovalifolius (Schumacher) J. Leonard Plants Compositae	Others
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .

HY-N12192

Ebenifoline E-II	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Euonymus laxiflorus Champ. ex Benth. Plants	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

HY-N1318

Salvigenin 2 Publications Verification Psathyrotin	Structural Classification Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-N3722

O-Demethylmurrayanine	Structural Classification Monophenols Clausena lansium (Lour.) Skeels Source classification Rutaceae Phenols Plants	Others
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC₅₀ values in the range 4.42-7.59 μg/mL .

HY-N12128

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-N3057

Pinostrobin chalcone	Flavonoids Chalcones Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer Cajanus cajan (L.) Millsp.	Others
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N8739

2-Hydroxyxanthone	Structural Classification Flavonoids Calophyllum inophyllum L. Source classification Plants Calophyllaceae Other Flavonoids	Endogenous Metabolite
2-Hydroxyxanthone (Compound 3) is an isoprene flavone derived from Calophyllum inophyllum. 2-Hydroxyxanthone has an obvious killing effect on K562 cells .

HY-N11519

Polyporusterone C	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC₅₀s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .

HY-125098

Illudin S	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	DNA Alkylator/Crosslinker Apoptosis
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N3627

Coronalolide methyl este NSC 680073	Structural Classification Natural Products Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Others
Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC₅₀ values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively .

HY-N0446

10-Methoxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer	ADC Cytotoxin
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Alkaloids Structural Classification other families Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants	Parasite
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N3966

Goniodiol 8-acetate	Structural Classification Natural Products Goniothalamus amuyon (Bl.) Merr. Source classification Plants Annonaceae	Others
Goniodiol 8-acetate is a styrylpyrones that can be isolated from the leaves of Goniothalamus amuyon. Goniodiol 8-acetate has cytotoxic activity .

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	Others
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .

HY-N7161

3-O-(2'E,4'E-Decadienoyl)-ingenol	Structural Classification Terpenoids Source classification Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants	Others
3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC₅₀s of 8.22 μM and 6.67 μM, respectively .

HY-129144

Dihydrodehydrodiconiferyl alcohol	Structural Classification Anogeissus acuminata (Roxb. ex DC.) Guill. Monophenols Combretaceae Source classification Phenols Plants	Others
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

HY-N3626

Coronalolide	Triterpenes Structural Classification Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants	Others
Coronalolide is a natural triterpene with anticancer effects. Coronalolide exhibits a broad cytotoxic activity for human breast (BT474), gastric (KATO-3), lung (CHAGO), colon (SW-620), and liver (Hep-G2) cancer cell lines, with IC₅₀ values of 6.59 µg/mL, 5.85 µg/mL, 5.42 µg/mL, 4.98 µg/mL, and 6.41 µg/mL, respectively .

HY-N8270

Physalin H	Structural Classification Cardiacglycosides Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N12142

Anticancer agent 156	Structural Classification Classification of Application Fields Antibiotics Source classification Miliusa sinensis Finet et Gagnep. Plants Annonaceae Disease Research Fields Other Antibiotics Cancer	Others
Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .

HY-N7205

Glaucocalyxin D	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Solidago virgaurea L.	Others
Glaucocalyxin D is a ent-kauranoid-type diterpenoid that can be isolated from Rabdosia japonica. Glaucocalyxin D shows cytotoxicity against various human tumor cell lines. Glaucocalyxin D can be used for cancer research .

HY-N6711

Equisetin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	HIV Integrase
Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537 . Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity . Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria . Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections .

HY-N6954

Garcinone C 1 Publications Verification	Structural Classification other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Source classification Guttiferae Phenols Polyphenols Plants Disease Research Fields Cancer	ATM/ATR STAT CDK
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner .

Species:	Human (6) Rhesus Macaque (1) Rat (3) Cynomolgus (2)
Tag:	His (8) Fc (4)
Source:	HEK293 (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P77106

	NKp30/NCR3 Protein, Rat (HEK293, His) natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3	Rat	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on natural killer (NK) cells that activates cytotoxicity by binding to ligands such as BAG6 and NCR3LG1, stimulating NK cells to respond against neighboring cells (including tumor cells) expressing these ligands. NKp30/NCR3 Protein, Rat (HEK293, His) is the recombinant rat-derived NKp30/NCR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of NKp30/NCR3 Protein, Rat (HEK293, His) is 129 a.a., with molecular weight of ~25-33 KDa.

HY-P70174

	NKp46/NCR1 Protein, Human (HEK293, Fc) rHunatural cytotoxicity Triggering Receptor 1/NCR1, Fc; natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293
	NKp46/NCR1 Protein is a major NK cell-activating receptor that is involved in the elimination of target cells and recognizing a wide range of tumors, viruses, and bacteria. NKp46 forms microclusters structures at the immune synapse between NK cells and target cells. Over-expression of human NKp46 is correlated with increased accumulation of F-actin mesh at the immune synapse. NKp46 signaling directly regulates the NK lytic immune synapse from early formation to late function. NKp46/NCR1 Protein, Human (HEK293, Fc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKp46/NCR1 Protein, Human (HEK293, Fc) is 233 a.a., with molecular weight of ~66.0 kDa.

HY-P72502

	NKp44/NCR2 Protein, Human (169a.a, HEK293, His) natural cytotoxicity triggering receptor 2; NKp44; CD336; NCR2; LY95	Human	HEK293
	The NKp44/NCR2 protein is a cytotoxicity-activating receptor on natural killer (NK) cells that may increase their tumor cell lysis efficiency. NKp44/NCR2 interacts with TYROBP/DAP12, an important signal transduction adapter, and is critical for transducing signals that activate NK cells against target cells. NKp44/NCR2 Protein, Human (169a.a, HEK293, His) is the recombinant human-derived NKp44/NCR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NKp44/NCR2 Protein, Human (169a.a, HEK293, His) is 169 a.a., with molecular weight of 30-38 kDa.

HY-P72839

	B7-H6 Protein, Human (HEK293, Fc) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Human	HEK293
	B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Human (HEK293, Fc) is the recombinant human-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H6 Protein, Human (HEK293, Fc) is 262 a.a., with molecular weight of ~53.4 kDa.

HY-P74685

	NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His) natural cytotoxicity triggering receptor 2; NKp44; CD336; NCR2; LY95	Human	HEK293
	The NKp44/NCR2 protein is a cytotoxicity-activating receptor on natural killer (NK) cells that may increase their tumor cell lysis efficiency. NKp44/NCR2 interacts with TYROBP/DAP12, an important signal transduction adapter, and is critical for transducing signals that activate NK cells against target cells. NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His) is the recombinant human-derived NKp44/NCR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His) is 169 a.a., with molecular weight of ~20 kDa.

HY-P75483

	B7-H6 Protein, Rat (HEK293, His) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Rat	HEK293
	B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H6 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H6 Protein, Rat (HEK293, His) is 308 a.a., with molecular weight of ~35.1 kDa.

HY-P75484

	B7-H6 Protein, Rat (HEK293, Fc) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Rat	HEK293
	B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Rat (HEK293, Fc) is the recombinant rat-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H6 Protein, Rat (HEK293, Fc) is 308 a.a., with molecular weight of ~60.4 kDa.

HY-P76742

	B7-H6 Protein, Cynomolgus (HEK293, Fc) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Cynomolgus	HEK293
	B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76743

	B7-H6 Protein, Cynomolgus (HEK293, His) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Cynomolgus	HEK293
	B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77452

	NKp30/NCR3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) NCR3 Protein; natural cytotoxicity Triggering Receptor 3; NCR3; CD337; 1C7; LY117	Rhesus Macaque	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on natural killer (NK) cells that activates cytotoxicity by binding to ligands such as BAG6 and NCR3LG1, stimulating NK cells to respond against neighboring cells (including tumor cells) expressing these ligands. NKp30/NCR3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived NKp30/NCR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of NKp30/NCR3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is 117 a.a., with molecular weight of ~23-32 kDa.

HY-P72506

	NKp30/NCR3 Protein, Human (120a.a, HEK293, His) NCR3 Protein; natural cytotoxicity Triggering Receptor 3; NCR3; CD337; 1C7; LY117	Human	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on NK cells and is activated by binding to ligands such as BAG6 and NCR3LG1. This activation enhances NK cell cytotoxicity against neighboring cells that produce these ligands, including tumor cells. NKp30/NCR3 Protein, Human (120a.a, HEK293, His) is the recombinant human-derived NKp30/NCR3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NKp30/NCR3 Protein, Human (120a.a, HEK293, His) is 120 a.a., with molecular weight of 20-31 kDa.

HY-P7631

	B7-H6 Protein, Human (HEK293, His) rHuB7-H6, His; B7 homolog 6; B7-H6; NCR3LG1; natural cytotoxicity triggering receptor 3 ligand 1	Human	HEK293
	B7-H6 Protein, Human (HEK293, His) suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis.

Cat. No.	Product Name	Chemical Structure

HY-N1318S

Salvigenin-d9
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties[1][2].

HY-W015307S

4-Ethyloctanoic acid-13C2
4-Ethyloctanoic acid- ¹³C₂ is ¹³C labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

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